Publications

 *: equality contributed, ✝: corresponding author

2024

Takada S, Komatsu M✝, Morishita H✝.
Method to Purify Phase-Separated p62 Bodies Using Fluorescence-Activated Particle Sorting.
Methods Mol Biol 2845:191-196, 2024
DOI: 10.1007/978-1-0716-4067-8_15

Kurusu R, Morishita H, Komatsu M✝.
p62 bodies: cytosolic zoning by phase separation.
J Biochem 175(2):141-146, 2024
DOI: 10.1093/jb/mvad089

Kurusu R*, Morishita H*✝, Komatsu M✝
Vault-phagy: a phase-separation-mediated selective autophagy of vault, a non-membranous organelle.
Autophagy 20(2):441-442, 2024
DOI: 10.1080/15548627.2023.2266996

2023

Kurusu R*, Fujimoto Y*, Morishita H*✝, Noshiro D, Takada S, Yamano K, Tanaka H, Arai R, Kageyama S, Funakoshi T, Komatsu-Hirota S, Taka H, Kazuno S, Miura Y, Koike M, Wakai T, Waguri S, Noda NN, Komatsu M✝
Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex.
Dev Cell 58: 1189-1205.e11, 2023
DOI: 10.1016/j.devcel.2023.04.015
※press release(AMED) https://www.amed.go.jp/news/seika/files/000112973.pdf

Ikeda R, Noshiro D, Morishita H, Takada S, Kageyama S, Fujioka Y, Funakoshi T, Komatsu-Hirota S, Arai R, Ryzhii E, Abe M, Koga T, Motohashi H, Nakao M, Sakimura K, Horii A, Waguri S, Ichimura Y✝, Noda NN✝, Komatsu M✝
Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response.
EMBO J 42:e113349, 2023
DOI: 10.15252/embj.2022113349
※press release https://prtimes.jp/main/html/rd/p/000000546.000021495.html

Liton PB✝, Boesze-Battaglia K, Boulton ME, Boya P, Ferguson TA, Ganley IG, Kauppinnen A, Laurie GW, Mizushima N, Morishita H, Russo R, Sadda J, Shyam R, Sinha D, Thompson DA, Zacks DN✝
Autophagy in the eye: from physiology to pathophysiology
Autophagy Rep 2(1):2178996, 2023
DOI: 10.1080/27694127.2023.2178996

2022

Morishita H✝
Role of autophagy in the eye: from physiology to disease.
Curr Opi Physiol 29, 100592, 2022
DOI: https://doi.org/10.1016/j.cophys.2022.100592

Morishita H✝, Komatsu M✝
Role of autophagy in liver disease.
Curr Opi Physiol 29, 100594, 2022
DOI: https://doi.org/10.1016/j.cophys.2022.100594

Hama Y*, Morishita H*, Mizushima N✝
Regulation of ER-derived membrane dynamics by the DedA domain-containing proteins VMP1 and TMEM41B.
EMBO Rep 23, e53894, 2022
DOI: 10.15252/embr.202153894

2021

Morishita H✝, Eguchi T, Mizushima N✝
A new insight into the lens: cytosolic PLAAT phospholipases degrade organelles to make the lens transparent.
Autophagy 17, 2645-2647, 2021
DOI: 10.1080/15548627.2021.1950372

Morishita H✝, Eguchi T, Tsukamoto S, Sakamaki Y, Takahashi S, Saito C, Koyama-Honda I, Mizushima N✝
Organelle degradation in the lens by PLAAT phospholipases.
Nature 592, 634-638, 2021
DOI: 10.1038/s41586-021-03439-w
※Preview (Nature) https://www.nature.com/articles/d41586-021-00888-1
※Preview (Dev Cell) https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00438-X
※H1 Connect (faculty of 1000): https://connect.h1.co/article/739937468?key=rjT7E8QnqisKJG6
※press release https://www.m.u-tokyo.ac.jp/news/admin/release_20210414-2.pdf

Mimura K, Sakamaki J, Morishita H, Kawazu M, Mano H, Mizushima N✝.
Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy.
J Biol Chem 296:100780, 2021
DOI: 10.1016/j.jbc.2021.100780

Morishita H, Kanda Y, Mizushima N✝
No air without autophagy: autophagy is important for lung and swim bladder inflation.
Autophagy 17, 1040-1041, 2021
DOI: 10.1080/15548627.2021.1885148

Okawa F*, Hama Y*, Zhang S*, Morishita H, Yamamoto H, Levine TP, Mizushima N✝
Evolution and insights into the structure and function of the DedA superfamily containing TMEM41B and VMP1.
J Cell Sci 134 jcs.255877, 2021
DOI: 10.1242/jcs.255877

Klionsky D✝,,,,Morishita H, (many authors)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy 17, 1-382, 2021
DOI: 10.1080/15548627.2020.1797280

Eguchi T, Morishita H, Mizushima N✝
Monitoring autophagic activity in vitro and in vivo using the GFP-LC3-RFP-LC3dG probe.
Neuromethods 171, 41-52, 2021
DOI: 10.1007/978-1-0716-1589-8_4

2020

Morishita H, Kanda Y, Kaizuka T, Chino H, Nakao K, Miki Y, Taketomi Y, Guan J-L, Murakami M, Aiba A, Mizushima N✝
Autophagy is required for maturation of surfactant-containing lamellar bodies in the lung and swim bladder.
Cell Rep 33: 108477-108477, 2020
DOI: 10.1016/j.celrep.2020.108477
※press release https://www.jst.go.jp/pr/announce/20201209/pdf/20201209.pdf

2019

Morishita H, Zhao YG*, Tamura N*, Nishimura T, Kanda Y, Sakamaki Y, Okazaki M, Li D, Mizushima N✝
A critical role of VMP1 in lipoprotein secretion.
eLife 8:e48834, 2019
DOI: 10.7554/eLife.48834
※press release https://www.m.u-tokyo.ac.jp/news/admin/release_20190917.pdf

Morishita H✝, Mizushima N✝
Diverse cellular roles of autophagy.
Annu Rev Cell Dev Biol 35:453-475, 2019
DOI: 10.1146/annurev-cellbio-100818-125300

2018

Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, Sakamaki Y, Mimura K, Morishita H, Shihoya W, Nureki O, Mano H, Mizushima N✝
Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation.
J Cell Biol 217: 3817-3828, 2018
DOI: 10.1083/jcb.201804132
※press release https://www.m.u-tokyo.ac.jp/news/admin/release_20180809.pdf

2017

Morishita H, Kaizuka T, Hama Y, Mizushima N✝
A new probe to measure autophagic flux in vitro and in vivo.
Autophagy 13:757-758, 2017
DOI: 10.1080/15548627.2016.1278094

Fujimoto C, Iwasaki S, Urata S, Morishita H, Sakamaki Y, Fujioka M, Kondo K, Mizushima N, Yamasoba T✝
Autophagy is essential for hearing in mice.
Cell Death Dis. 8:e2780, 2017
DOI: 10.1038/cddis.2017.194

2016

Kaizuka T*, Morishita H*, Hama Y, Tsukamoto S, Matsui T, Toyota Y, Kodama A, Ishihara T, Mizushima T, Mizushima N✝
An autophagic flux probe that releases an internal control.
Mol Cell 64(4), 835-49, 2016
DOI: 10.1016/j.molcel.2016.09.037
※press release https://www.m.u-tokyo.ac.jp/news/admin/release_20161107.pdf
※Meet the Author (Mol Cell) https://www.cell.com/molecular-cell/meet-the-author/kaizuka-morishita?src=page

Morishita H, Mizushima N✝
Autophagy in the lens.
Exp Eye Res. 144:22-28, 2016
DOI: 10.1016/j.exer.2015.08.019

Tsuboyama K*, Koyama-Honda I*, Sakamaki Y, Koike M, Morishita H, Mizushima N✝
The ATG conjugation systems are important for degradation of the inner autophagosomal membrane.
Science 354(6315), 1036-41, 2016
DOI: 10.1126/science.aaf6136
※Preview (Science): https://www.science.org/doi/10.1126/science.aal3145?intcmp=trendmd-sci

2013

Morishita H, Eguchi S, Kimura H, Sasaki J, Sakamaki Y, Robinson ML, Sasaki T, Mizushima N✝
Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation.
J Biol Chem 288(16): 11436-47, 2013
DOI: 10.1074/jbc.M112.437103

2009

Morishita H, Saito F, Kayama H, Atarashi K, Kuwata H, Yamamoto M, Takeda K✝
Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses.
Int. Immunol. 21:457-465, 2009
DOI: 10.1093/intimm/dxp015

2006

Kuwata H, Matsumoto H, Atarashi K, Morishita H, Hirotani T, Koga R, Takeda K✝
IκBNS inhibits induction of subset of Toll-like receptor-dependent genes and limits inflammation.
Immunity 24:41-51, 2006
DOI: 10.1016/j.immuni.2005.11.004